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Any condition that affects the quantity, structure, or lifespan of haemoglobin — such as anaemia, haemoglobinopathies, or other red blood cell disorders — can distort HbA1c values and lead to misleading estimates of average blood glucose, the Lancet viewpoint article notes.

​Any condition that affects the quantity, structure, or lifespan of haemoglobin — such as anaemia, haemoglobinopathies, or other red blood cell disorders — can distort HbA1c values and lead to misleading estimates of average blood glucose, the Lancet viewpoint article notes.